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Article

Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism.

Endocrinology - 6 May 2026

Lee Hye Kyung, Pyatkov Maxim, Gavrilova Oksana, Liu Naili, Demby Tamar, Ye Bingtian, Furth Priscilla A, Hennighausen Lothar, Waxman David J

Abstract excerpt

Growth hormone (GH) signaling through signal transducer and activator of transcription 5 (STAT5B) is a central regulator of hepatic metabolism, yet the functional consequences of disease-associated STAT5B variants remain poorly understood. Here, we analyzed mice carrying STAT5BY665F (gain-of-function) and STAT5BY665H (loss-of-function) variants and dissect their impact on metabolic regulation. STAT5BY665F mice...

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Share to Cholesterol
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42084328
DOI: 10.1210/endocr/bqag057
PMCID: PMC13176614

Genes

STAT5B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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