Stat proteins and oncogenesis

Abstract excerpt

JAK-STAT signaling in human diseaseThe discovery of Stat proteins' key role in IFN signaling, initially described over ten years ago, provided the first molecular link of growth factor receptor stimulation to the direct activation of a transcription factor (1). Since that time a large number of growth factor receptors and some nonreceptor tyrosine kinases have been found to lead to the activation of these...

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