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Article

Disease-Associated Mutations of the STAT5B SH2 Domain Regulate Cytokine-Driven Enhancer Function and Mammary Development.

Journal of mammary gland biology and neoplasia - 31 Mar 2025

Lee Hye Kyung, Jankowski Jakub, Liu Chengyu, Hennighausen Lothar

Abstract excerpt

Mammary gland development during pregnancy is controlled by lactogenic hormones via the JAK2-STAT5 pathway. Gene deletion studies in mice have revealed the crucial roles of both STAT5A and STAT5B in establishing the genetic programs necessary for the development of mammary epithelium and successful lactation. Several hundred single nucleotide polymorphisms (SNPs) have been identified in human STAT5B, although...

Topics

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Cytokines
Epigenome
Fatty Acids
Mammary Glands, Animal
Protein Multimerization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

src Homology Domains

STAT5 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 40163145
DOI: 10.1007/s10911-025-09582-8
PMCID: PMC11958444

Genes

STAT5B
JAK2
STAT5A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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