Article

Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism

2025-12-01

Abstract excerpt

Growth hormone (GH) signaling through STAT5B is a central regulator of hepatic metabolism, yet the functional consequences of disease-associated STAT5B variants remain poorly understood. Here, we analyzed mice carrying STAT5B Y665F (gain-of-function) and STAT5B Y665H (loss-of-function) variants and dissect their impact on metabolic regulation. STAT5B Y665F mice developed hepatic lipid accumulation, hypercholest...

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Literature Corpus work: 3b7e0ab0-7282-5010-8350-ff8a4f60a5b7
DOI: 10.1101/2025.11.27.691004

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