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Serine residues 726 and 780 have nonredundant roles regulating STAT5a activity in luminal breast cancer

29 Jun 2021

Abstract excerpt

In breast cancer, prolactin-induced activation of the transcription factor STAT5a results from the phosphorylation of STAT5a tyrosine residue 694. However, its role in mammary oncogenesis remains an unsettled debate as STAT5a exhibits functional dichotomy with both pro-differentiative and pro-proliferative target genes. Phosphorylation of STAT5a serine residues, S726 and S780, may regulate STAT5a in such a way to...

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PMID: 34188118
DOI: 10.1038/s41598-021-92830-8

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