Article

STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs

2024-12-22

Abstract excerpt

<h4>Summary</h4> STAT5B is a vital transcription factor for lymphocytes. Here, function of two STAT5B mutations from human T cell leukemias: one substituting tyrosine 665 with phenylalanine (STAT5B Y665F ), the other with histidine (STAT5B Y665H ) was interrogated. In silico modeling predicted divergent energetic effects on homodimerization with a range of pathogenicity. In primary T cells in vitro STAT5B Y6...

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Literature Corpus work: 90cc9923-4e5e-5836-bcfa-3eac0e925761
DOI: 10.1101/2024.12.20.629685

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