Article

A genome-wide CRISPR screen identifies ZCCHC14 as a host factor required for hepatitis B surface antigen production

2019-07-30

Abstract excerpt

<h4>GRAPHICAL ABSTRACT</h4> <h4>SUMMARY</h4> A hallmark of chronic hepatitis B virus (CHB) infection is the presence of high circulating levels of non-infectious small lipid HBV surface antigen (HBsAg) vesicles. Although rare, sustained HBsAg loss is the idealized endpoint of any CHB therapy. A novel small molecule RG7834 has been previously reported to inhibit HBsAg expression by targeting terminal nucleotidylt...

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Literature Corpus work: af7c7108-df3a-5689-8b55-1f4190aa2863
DOI: 10.1101/718940

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