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Genetically edited hepatic cells expressing the NTCP-S267F variant are resistant to hepatitis B virus infection

10 Nov 2021

Abstract excerpt

The sodium-dependent taurocholate co-transporting polypeptide (NTCP)-S267F variant is known to be associated with a reduced risk of hepatitis B virus (HBV) infection and disease progression. The NTCP-S267F variant displays diminished function in mediating HBV entry, but its function in HBV infection has not been fully established in more biologically relevant models. We introduced the NTCP-S267F variant and...

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PMID: 34853804
DOI: 10.1016/j.omtm.2021.11.002

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