Article
Identification of novel susceptibility loci associated with hepatitis B surface antigen seroclearance in chronic hepatitis B.
PloS one - 1 Jan 2018
Kim Tae Hyung, Lee Eun-Ju, Choi Ji-Hye, Yim Sun Young, Lee Sunwon, Kang Jaewoo, Lee Yoo Ra, Lee Han Ah, Choi Hyuk Soon, Kim Eun Sun, Keum Bora, Seo Yeon Seok, Yim Hyung Joon, Jeen Yoon Tae, Chun Hoon Jai, Lee Hong Sik, Kim Chang Duck, Woo Hyun Goo, Um Soon Ho
Abstract excerpt
BACKGROUND/AIMS: The seroclearance of hepatitis B virus (HBV) surface antigen (HBsAg) is regarded as a functional cure of chronic hepatitis B (CHB) although it occurs rarely. Recently, several genome-wide association studies (GWASs) revealed various genetic alterations related to the clinical course of HBV infection. However, all of these studies focused on the progression of HBV infection to chronicity and had...
Topics
- Adult
- Aged
- Chemokine CXCL13
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Hepatitis B Surface Antigens
- Hepatitis B virus