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Orthogonal CRISPR screens and human liver chimeric mice identify hepatitis B virus host factors

2026-07-24

Abstract excerpt

Hepatitis B virus (HBV) chronically infects approximately 250 million people worldwide, and reliable curative therapies are lacking. A broader understanding of viral-host interactions could accelerate efforts to find new host-centric therapeutic targets. However, inefficient cell culture systems and limited replication markers compatible with pooled screening have precluded the widespread use of genetic perturbati...

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Literature Corpus work
8077aee6-d2ba-528c-a9e4-35178d13383d
DOI
10.64898/2026.07.23.740386
Open publication

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Orthogonal CRISPR screens and human liver chimeric mice identify hepatitis B virus host factorsDOI 10.64898/2026.07.23.740386
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