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ZNF638 represses the transcription of HBV closed circular DNA involving HUSH complex-mediated histone modifications of epigenetic silencing

2025-05-15

Abstract excerpt

Hepatitis B virus (HBV) infection poses a critical threat to public health burden worldwide. As the major template of viral transcription, the covalently closed circular DNAs (cccDNAs) of HBV was known to form microchromosomes and interact with various host proteins. In the present study, ZNF638 was found to significantly reduce the transcription of HBV into pgRNAs, and subsequently reduce cccDNA formation and vir...

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Literature Corpus work
261aabf7-2d24-52af-80c3-ed49e769fc54
DOI
10.1101/2025.05.15.654218
Open publication

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ZNF638 represses the transcription of HBV closed circular DNA involving HUSH complex-mediated histone modifications of epigenetic silencingDOI 10.1101/2025.05.15.654218
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