Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRISPR-Cas13b-mediated suppression of HBV replication and protein expression

28 May 2024

Abstract excerpt

BACKGROUND & AIMS: New antiviral approaches that target multiple aspects of the HBV replication cycle to improve rates of functional cure are urgently required. HBV RNA represents a novel therapeutic target. Here, we programmed CRISPR-Cas13b endonuclease to specifically target the HBV pregenomic RNA and viral mRNAs in a novel approach to reduce HBV replication and protein expression. METHODS: Cas13b CRISPR RNAs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Hepatitis B Virus Studies
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38815932
DOI: 10.1016/j.jhep.2024.05.025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRISPR-Cas13b-mediated suppression of HBV replication and protein expressionPMID 38815932Read ↗

Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system to disrupt the hepatitis B virus.Semantic proximity Read ↗

Recent Progress and Future Prospective in HBV Cure by CRISPR/CasSemantic proximity Read ↗

CRISPR/Cas9 for hepatitis B virus infection treatmentSemantic proximity Read ↗

Application of CRISPR/Cas9 Technology to HBVSemantic proximity Read ↗

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virusSemantic proximity Read ↗

Development of an in vivo delivery system for CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNASemantic proximity Read ↗

CRISPR/Cas13-assisted hepatitis B virus covalently closed circular DNA detectionSemantic proximity Read ↗

CRISPR/Cas and Hepatitis B Therapy: Technological Advances and Practical BarriersSemantic proximity Read ↗

Efficient silencing of hepatitis B virus S gene through CRISPR‐mediated base editingSemantic proximity Read ↗

Synthetic gRNA/Cas9 ribonucleoprotein targeting HBV DNA inhibits viral replicationSemantic proximity Read ↗

An Effective Molecular Target Site in Hepatitis B Virus S Gene for Cas9 Cleavage and Mutational Inactivation.Semantic proximity Read ↗

Complete Spectrum of CRISPR/Cas9-induced Mutations on HBV cccDNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.