Article

Epistasis between mutator alleles contributes to germline mutation spectra variability in laboratory mice

2023-04-25

Abstract excerpt

Maintaining germline genome integrity is essential and enormously complex. Although many proteins are involved in DNA replication, proofreading, and repair [1], mutator alleles have largely eluded detection in mammals. DNA replication and repair proteins often recognize sequence motifs or excise lesions at specific nucleotides. Thus, we might expect that the spectrum of de novo mutations — the frequencies of C>...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: af71586f-a081-5c43-8f07-0c9d35e24f6d
DOI: 10.1101/2023.04.25.537217

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epistasis between mutator alleles contributes to germline mutation spectra variability in laboratory miceDOI 10.1101/2023.04.25.537217Read

Epistasis between mutator alleles contributes to germline mutation spectrum variability in laboratory mice.Semantic proximity Read

A natural mutator allele shapes mutation spectrum variation in mice.Semantic proximity Read

A natural mutator allele shapes mutation spectrum variation in miceSemantic proximity Read

Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice.Semantic proximity Read

Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosineSemantic proximity Read

A maternal germline mutator phenotype in a family affected by heritable colorectal cancerSemantic proximity Read

Variation in the Spectrum of New Mutations among Inbred Strains of Mice.Semantic proximity Read

Inference of candidate germline mutator loci in humans from genome-wide haplotype dataSemantic proximity Read

Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine.Semantic proximity Read

A novel quantitative trait locus implicates <i>Msh3</i> in the propensity for genome-wide short tandem repeat expansions in miceSemantic proximity Read

Heterozygous deleterious MUTYH variants as a driver for tumorigenesisSemantic proximity Read

A NHEJ1 mutator allele influencing germline mutation rates sex-specifically in humans.Semantic proximity Read