Article

Heterozygous deleterious MUTYH variants as a driver for tumorigenesis

2021-06-13

Abstract excerpt

MUTYH is a glycosylase involved in the base excision repair of the DNA. Biallelic mutations in the MUTYH gene cause the autosomal recessive condition known as MUTYH-associated adenomatous polyposis and increase colorectal cancer risk. However, the cancer risk associated with germline variants in individuals carrying only one MUTYH defective allele is controversial and based on studies involving few samples. Here,...

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Literature Corpus work: 7e5d3176-cff4-5a42-9696-41349d824cf8
DOI: 10.1101/2021.06.09.21258588

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