Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A natural mutator allele shapes mutation spectrum variation in mice.

Nature - 1 May 2022

Sasani Thomas A, Ashbrook David G, Beichman Annabel C, Lu Lu, Palmer Abraham A, Williams Robert W, Pritchard Jonathan K, Harris Kelley

Abstract excerpt

Although germline mutation rates and spectra can vary within and between species, common genetic modifiers of the mutation rate have not been identified in nature1. Here we searched for loci that influence germline mutagenesis using a uniquely powerful resource: a panel of recombinant inbred mouse lines known as the BXD, descended from the laboratory strains C57BL/6J (B haplotype) and DBA/2J (D haplotype). Each...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Haplotypes
Share to Alleles
Share to Germ-Line Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mammals

Share to Mice, Inbred C57BL

Share to Mice, Inbred DBA

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 35545679
DOI: 10.1038/s41586-022-04701-5
PMCID: PMC9272728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A natural mutator allele shapes mutation spectrum variation in mice.PMID 35545679Read ↗

A natural mutator allele shapes mutation spectrum variation in miceSemantic proximity Read ↗

Epistasis between mutator alleles contributes to germline mutation spectra variability in laboratory miceSemantic proximity Read ↗

Epistasis between mutator alleles contributes to germline mutation spectrum variability in laboratory mice.Semantic proximity Read ↗

Striking differences in patterns of germline mutation between mice and humansSemantic proximity Read ↗

Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice.Semantic proximity Read ↗

Variation in the Spectrum of New Mutations among Inbred Strains of Mice.Semantic proximity Read ↗

Evolution of the Mutation Spectrum Across a Mammalian Phylogeny.Semantic proximity Read ↗

Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosineSemantic proximity Read ↗

The rate and spectrum of new mutations in mice inferred by long-read sequencing.Semantic proximity Read ↗

Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine.Semantic proximity Read ↗

Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing.Semantic proximity Read ↗

Inference of candidate germline mutator loci in humans from genome-wide haplotype dataSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.