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Article

A NHEJ1 mutator allele influencing germline mutation rates sex-specifically in humans.

Science advances - 31 Jul 2026

Wu Kun, Nan Jiuhong, Liu Haoxuan

Abstract excerpt

Germline mutations play a pivotal role in evolution and are the primary cause of hereditary diseases in humans. Although interpopulation and interspecific variations in the mutation rate and spectrum are observed, their underlying genetic basis is still unclear. In this study, we explore the genetic regulation of germline mutation rates using one of the largest publicly available datasets derived from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42536752
DOI: 10.1126/sciadv.aed2571
PMCID: PMC13426420

Genes

NHEJ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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