Back to search

Article

A novel quantitative trait locus implicates <i>Msh3</i> in the propensity for genome-wide short tandem repeat expansions in mice

2022-03-02

Abstract excerpt

Short tandem repeats (STRs) are a class of rapidly mutating genetic elements characterized by repeated units of 1 or more nucleotides. We leveraged whole genome sequencing data for 152 recombinant inbred (RI) strains from the BXD family derived from C57BL/6J and DBA/2J mice to study the effects of genetic background on genome-wide patterns of new mutations at STRs. We defined quantitative phenotypes describing the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
51a9ee1f-66d2-5383-9b47-3e33980297b5
DOI
10.1101/2022.03.02.482700
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A novel quantitative trait locus implicates <i>Msh3</i> in the propensity for genome-wide short tandem repeat expansions in miceDOI 10.1101/2022.03.02.482700
A Tandem Repeat Atlas for the Genome of Inbred Mouse Strains: A Genetic Variation ResourceSemantic proximity
Polymorphic SNPs, short tandem repeats and structural variants are responsible for differential gene expression across C57BL/6 and C57BL/10 substrainsSemantic proximity
The rate and spectrum of new mutations in mice inferred by long-read sequencing.Semantic proximity
A Murine Database of Structural Variants Enables the Genetic Architecture of a Spontaneous Murine Lymphoma to be CharacterizedSemantic proximity
Resolution of structural variation in diverse mouse genomes reveals chromatin remodeling due to transposable elementsSemantic proximity
A Murine Database of Structural Variants Identifies A Candidate Gene for a Spontaneous Murine Lymphoma Model.Semantic proximity
Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation, and homozygous truncating mutationsSemantic proximity
Sequence-based characterization of structural variation in the mouse genome.Semantic proximity
The mutational dynamics of short tandem repeats in large, multigenerational families.Semantic proximity
Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in <i> Nlrp3 <sup>−/−</sup> </i> miceSemantic proximity
A natural mutator allele shapes mutation spectrum variation in miceSemantic proximity
Epistasis between mutator alleles contributes to germline mutation spectra variability in laboratory miceSemantic proximity
Select a neighboring publication to make it the new centre.