Article

LRRK2 Phosphorylates Neuronal Elav RNA-Binding Proteins to Regulate Phenotypes Relevant to Parkinson’s Disease

2022-04-25

Abstract excerpt

Parkinson’s disease (PD) is characterized by accumulation of α -synuclein and the loss of dopaminergic neurons. Mutations which cause an increase in the kinase activity of Leucine-Rich-Repeat Kinase-2 (LRRK2) are a major inherited cause of PD. Research continues to determine which targets LRRK2 phosphorylates to cause disease. Polymorphisms in the locus of ELAVL4, an RNA-binding protein are a risk-factor for Par...

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Literature Corpus work: af5f9e6a-2257-5868-9e4a-d33054b3cb8e
DOI: 10.1101/2022.04.24.489327

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