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Article

Identification of Targets from LRRK2 Rescue Phenotypes.

Cells - 5 Jan 2021

Toh Joanne, Chua Ling Ling, Ho Patrick, Sandanaraj Edwin, Tang Carol, Wang Hongyan, Tan Eng King

Abstract excerpt

Parkinson's disease (PD) is an age-dependent neurodegenerative condition. Leucine-rich repeat kinase 2 (LRRK2) mutations are the most frequent cause of sporadic and autosomal dominant PD. The exact role of LRRK2 protective variants (R1398H, N551K) together with a pathogenic mutant (G2019S) in aging and neurodegeneration is unknown. We generated the following myc-tagged UAS-LRRK2 transgenic Drosophila: LRRK2 (WT),...

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Identifiers

PMID: 33466414
DOI: 10.3390/cells10010076
PMCID: PMC7824855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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