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Article

Leucine-rich repeat kinase 2 and alternative splicing in Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2012

Elliott David A, Kim Woojin S, Gorissen Sarsha, Halliday Glenda M, Kwok John B J

Abstract excerpt

Mutations of the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson's disease (PD) and are associated with pleiomorphic neuropathology. We hypothesize that LRRK2 mediates its pathogenic effect through alternative splicing of neurodegeneration genes. Methods used in this study included western blotting analysis of subcellular protein fractions, exon-array analysis of RNA from...

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PMID: 22528366
DOI: 10.1002/mds.25005

Genes

DST
SNCA
FUS
TARDBP

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