Article

High extracellular lactate increases reductive carboxylation in breast tissue cell lines grown under normoxic conditions

2019-02-23

Abstract excerpt

In cancer tumors, lactate accumulation was initially attributed to high glucose consumption associated with the Warburg Effect. Now it is evident that lactate can also serve as an energy source in cancer cell metabolism. Additionally, lactate has been shown to promote metastasis, generate gene expression patterns in cancer cells consistent with “cancer stem cell” phenotypes, and result in treatment resistant tumor...

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Literature Corpus work: af13f13f-4aed-5c74-b8eb-1512c8f5c37b
DOI: 10.1101/558296

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