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Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells

14 Jan 2020

Abstract excerpt

Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding transcription factors, cell division and cell proliferation in MCF7 cells, a human breast cancer cell line. Gene transcription was compared between MCF7 cells...

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PMID: 32010625
DOI: 10.3389/fonc.2019.01536

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