Article

Divergent use of metabolic fluxes in breast cancer metastasis

2020-08-04

Abstract excerpt

<h4>Summary</h4> Breast cancers can metastasize to many organs. But how do disseminated cells from a primary tumor adapt to distal tissues? Here we combined metabolomics, flux measurements, and mathematical modeling to study metabolic fluxes in breast cancer cells adapted to home to different organs. We found that lung-homing cells maintain high glycolytic flux despite low levels of glycolytic intermediates, by c...

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Literature Corpus work: 6fea90d5-4dc3-5807-82bd-31322b5a806d
DOI: 10.1101/2020.08.03.234468

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