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Article

Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function.

Seminars in oncology - 1 Apr 2014

Martinez-Outschoorn Ubaldo, Sotgia Federica, Lisanti Michael P

Abstract excerpt

Metabolic synergy or metabolic coupling between glycolytic stromal cells (Warburg effect) and oxidative cancer cells occurs in human breast cancers and promotes tumor growth. The Warburg effect or aerobic glycolysis is the catabolism of glucose to lactate to obtain adenosine triphosphate (ATP). This review summarizes the main findings on this stromal metabolic phenotype, and the associated signaling pathways, as...

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PMID: 24787293
DOI: 10.1053/j.seminoncol.2014.03.002

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