Article
Metabolic symbiosis in cancer: refocusing the Warburg lens.
Molecular carcinogenesis - 1 May 2013
Nakajima Erica C, Van Houten Bennett
Abstract excerpt
Using relatively primitive tools in the 1920s, Otto Warburg demonstrated that tumor cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not. High rates of glucose uptake, fueling glycolysis, are now used clinically to identify cancer cells. However, the Warburg effect does not account for the metabolic diversity that has been observed...
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