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Article

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

1 Jun 2011

Abstract excerpt

Recently, we proposed a new mechanism for understanding the Warburg effect in cancer metabolism. In this new paradigm, cancer-associated fibroblasts undergo aerobic glycolysis, and extrude lactate to "feed" adjacent cancer cells, which then drives mitochondrial biogenesis and oxidative mitochondrial metabolism in cancer cells. Thus, there is vectorial transport of energy-rich substrates from the fibroblastic...

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PMID: 21558814
DOI: 10.4161/cc.10.11.15659

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