Article

The PI3K-Akt-CCND2 axis orchestrates macrophage M1 polarization through metabolic reprogramming: mechanistic and therapeutic insights

2026-02-20

Abstract excerpt

<title>Abstract</title> <p>Background Sepsis is a life-threatening syndrome driven by dysregulated macrophage polarization, in which excessive M1 polarization exacerbates systemic inflammation and organ injury. However, the mechanisms underlying the interplay between metabolic reprogramming and cell-cycle regulators such as Ccnd2 during macrophage polarization in sepsis remain poorly understood. This study inves...

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Literature Corpus work: b93200b2-e69a-5503-91c9-722843b76bc6
DOI: 10.21203/rs.3.rs-8674632/v1

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