Article

Immune-response gene 1 deficiency aggravates inflammation-triggered cardiac dysfunction by inducing M1 macrophage polarization and aggravating Ly6C high monocyte recruitment

2023-09-12

Abstract excerpt

<title>Abstract</title> <p>Background The role of immune response gene 1 (IRG1) and its product itaconate in sepsis-induced cardiac dysfunction (SIMD) has yet to be fully understood, despite its known anti-inflammatory and antioxidant effects mediated through diverse mechanisms. Methods In order to create an experimental sepsis model in vivo, mice were administered lipopolysaccharide (LPS) at a dosage of 10 mg/...

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Literature Corpus work: 61d6dcf8-fdf2-5d31-9b56-f542e0e93abd
DOI: 10.21203/rs.3.rs-3330820/v1

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