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Article

Dexmedetomidine Regulates Macrophage Phenotype Remodeling Through AMPK/SIRT1 to Alleviate Inflammatory Mediators and Lung Injury.

Journal of biochemical and molecular toxicology - 1 Jan 2025

Zhao Yi-Si, Shi Ya-Kang, Li Ke-Feng, Ma Bei, Lin Shi-Hui, Xing Yu, Xu Fang

Abstract excerpt

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality in the intensive care unit (ICU) and can cause excessive inflammation. Dexmedetomidine (DEX) is a drug that exerts anti-inflammatory effects. Identifying the anti-inflammatory mechanism of DEX in the context of ALI/ARDS possesses potential significance for the prevention and treatment of ARDS. In...

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PMID: 39692360
DOI: 10.1002/jbt.70108

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