Article

Integrative omics analysis reveals gene regulatory mechanisms distinguishing organoid-derived hepatocytes from primary human hepatocytes

2023-12-06

Abstract excerpt

<h4>Background and Aims</h4> Hepatic organoid cultures are considered a powerful model system to study liver development and diseases in vitro . However, hepatocyte-like cells differentiated from such organoids remain immature compared to primary human hepatocytes. Therefore, a comprehensive understanding of differences in gene regulatory mechanisms between primary human hepatocytes and hepatic organoids is esse...

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Literature Corpus work: aee8f347-0f43-5215-aff1-9bfc6ec7183a
DOI: 10.1101/2023.12.05.570132

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