Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis

29 Sept 2021

Abstract excerpt

Fibrosis is characterized by the excessive production of collagen and other extracellular matrix (ECM) components and represents a leading cause of morbidity and mortality worldwide. Previous studies of nonalcoholic steatohepatitis (NASH) with fibrosis were largely restricted to bulk transcriptome profiles. Thus, our understanding of this disease is limited by an incomplete characterization of liver cell types in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Liver Disease Diagnosis and Treatment
Share to Liver Diseases and Immunity
Share to Liver physiology and pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34588551
DOI: 10.1038/s41598-021-98806-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosisPMID 34588551Read ↗

Decoding liver fibrogenesis with single-cell technologiesSemantic proximity Read ↗

Single-cell transcriptomic profiling of healthy and fibrotic adult zebrafish liver reveals conserved cell identities and stellate cell activation phenotypes with human liverSemantic proximity Read ↗

Pan-fibrotic gene expression signature in major chronic diseases by integrative bulk and single-cell transcriptomic analysesSemantic proximity Read ↗

Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liverSemantic proximity Read ↗

Single-cell transcriptomics of hepatic stellate cells uncover crucial pathways and key regulators involved in non-alcoholic steatohepatitisSemantic proximity Read ↗

Key genes in the liver fibrosis process are mined based on single-cell transcriptomicsSemantic proximity Read ↗

Molecular characterization and cell type composition deconvolution of fibrosis in NAFLDSemantic proximity Read ↗

Understanding the cellular interactome of non-alcoholic fatty liver diseaseSemantic proximity Read ↗

Single-cell transcriptome and cell type-specific molecular pathways of human non-alcoholic steatohepatitisSemantic proximity Read ↗

Unraveling the activation process and core driver genes of HSCs during cirrhosis by single-cell transcriptomeSemantic proximity Read ↗

Transcriptomic Profiling of Obesity-Related Nonalcoholic Steatohepatitis Reveals a Core Set of Fibrosis-Specific GenesSemantic proximity Read ↗

Single‐cell RNA sequencing reveals the heterogeneity and intercellular communication of hepatic stellate cells and macrophages during liver fibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.