Article

A nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytes

2022-03-25

Abstract excerpt

<h4>Summary</h4> The capacity to generate functional hepatocytes from renewable human pluripotent stem cells (hPSCs) could address limited supplies of primary human hepatocytes. However, hepatocytes differentiated from hPSCs in vitro are functionally immature. To understand mechanisms regulating maturation of in vitro derived hepatocytes, we developed a 3D spheroid differentiation system and compared gene regul...

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Literature Corpus work: e3401397-3139-50fe-901b-c012718a1885
DOI: 10.1101/2022.03.24.485641

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