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Systemic Removal of Host Restriction Factors Enables Rapid, Scalable Virus Production for Cell Culture-Based Vaccines High-Yield Virus Production System generated by gene knockout of multiple anti-viral host factors

2026-03-30

Abstract excerpt

<title>Abstract</title> <p>The efficiency of cell culture-based vaccine production is fundamentally constrained by the antiviral defenses of host cells, creating a major bottleneck for rapid and large-scale vaccine manufacturing. Key antiviral proteins- such as RNase L, PKR, and JAK1 act as intrinsic brakes on viral replication, limiting efficient propagation of many clinically relevant viruses. To overcome this...

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Literature Corpus work: aee4b31d-1119-56da-affb-1a51b92c734a
DOI: 10.21203/rs.3.rs-9184882/v1

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