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Article

Gene-edited vero cells as rotavirus vaccine substrates

8 Oct 2019

Abstract excerpt

Rotavirus (RV) is a leading cause of severe gastroenteritis globally and can cause substantial morbidity associated with gastroenteritis in children <5 years of age. Orally administered live-attenuated RV vaccines offer protection against disease but vaccination efforts have been hampered by high manufacturing costs and the need to maintain a cold chain. A subset of Vero cell host genes was identified by siRNA...

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PMID: 31660537
DOI: 10.1016/j.jvacx.2019.100045

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