Virus Replication in Engineered Human Cells That Do Not Respond to Interferons

doi:10.1128/jvi.77.3.2174-2181.2003

Article

Virus Replication in Engineered Human Cells That Do Not Respond to Interferons

13 Jan 2003

Abstract excerpt

The V protein of the paramyxovirus simian virus 5 blocks interferon (IFN) signaling by targeting STAT1 for proteasome-mediated degradation. Here we report on the isolation of human cell lines that express the V protein and can no longer respond to IFN. A variety of viruses, particularly slow-growing wild-type viruses and vaccine candidate viruses (which are attenuated due to mutations that affect virus...

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