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Cell culture-based production and in vivo characterization of purely clonal defective interfering influenza virus particles

3 May 2021

Abstract excerpt

Abstract Background Infections with influenza A virus (IAV) cause high morbidity and mortality in humans. Additional to vaccination, antiviral drugs are a treatment option. Besides FDA-approved drugs such as oseltamivir or zanamivir, virus-derived defective interfering (DI) particles (DIPs) are considered promising new agents. IAV DIPs typically contain a large internal deletion in one of their eight genomic...

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PMID: 33941189
DOI: 10.1186/s12915-021-01020-5

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