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Combating viral contaminants in CHO cells by engineering innate immunity

20 Jun 2019

Abstract excerpt

Viral contamination in biopharmaceutical manufacturing can lead to shortages in the supply of critical therapeutics. To facilitate the protection of bioprocesses, we explored the basis for the susceptibility of CHO cells to RNA virus infection. Upon infection with certain ssRNA and dsRNA viruses, CHO cells fail to generate a significant interferon (IFN) response. Nonetheless, the downstream machinery for...

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PMID: 31222165
DOI: 10.1038/s41598-019-45126-x

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