Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibitors of the Interferon Response Enhance Virus Replication In Vitro

12 Nov 2014

Abstract excerpt

Virus replication efficiency is influenced by two conflicting factors, kinetics of the cellular interferon (IFN) response and induction of an antiviral state versus speed of virus replication and virus-induced inhibition of the IFN response. Disablement of a virus's capacity to circumvent the IFN response enables both basic research and various practical applications. However, such IFN-sensitive viruses can be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Respiratory viral infections research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25390891
DOI: 10.1371/journal.pone.0112014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibitors of the Interferon Response Enhance Virus Replication In VitroPMID 25390891Read ↗

JAK inhibitors remove innate immune barriers facilitating viral propagationSemantic proximity Read ↗

The Robust Restriction of Zika Virus by Type-I Interferon in A549 Cells Varies by Viral Lineage and Is Not Determined by IFITM3Semantic proximity Read ↗

Systemic Removal of Host Restriction Factors Enables Rapid, Scalable Virus Production for Cell Culture-Based Vaccines High-Yield Virus Production System generated by gene knockout of multiple anti-viral host factorsSemantic proximity Read ↗

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of InterferonsSemantic proximity Read ↗

The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type I Interferon SignalingSemantic proximity Read ↗

Novel activities by ebolavirus and marburgvirus interferon antagonists revealed using a standardized in vitro reporter systemSemantic proximity Read ↗

Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING PathwaySemantic proximity Read ↗

Selective Janus kinase inhibition preserves interferon-λ–mediated antiviral responsesSemantic proximity Read ↗

Virus Replication in Engineered Human Cells That Do Not Respond to InterferonsSemantic proximity Read ↗

IFN-λ1 Displays Various Levels of Antiviral Activity In Vitro in a Select Panel of RNA VirusesSemantic proximity Read ↗

The Screening and Mechanism of Influenza-Virus Sensitive MDCK Cell Lines for Influenza Vaccine ProductionSemantic proximity Read ↗

Two interferon-independent double-stranded RNA-induced host defense strategies suppress the common cold virus at warm temperatureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.