A pooled genome-wide screening strategy to identify and rank influenza host restriction factors in cell-based vaccine production platforms

Abstract excerpt

Cell-derived influenza vaccines provide better protection and a host of other advantages compared to the egg-derived vaccines that currently dominate the market, but their widespread use is hampered by a lack of high yield, low cost production platforms. Identification and knockout of innate immune and metabolic restriction factors within relevant host cell lines used to grow the virus could offer a means to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to CRISPR and Genetic Engineering
• Share to Influenza Virus Research Studies
• Share to Viral Infectious Diseases and Gene Expression in Insects