Article

Absence of surface IgD does not impair naive B cell homeostasis and memory B cell formation in humans

2018-05-28

Abstract excerpt

<h4>One Sentence Summary</h4> Human B cells with a genetic defect in IGHD develop normally in vivo , and do not have a competitive disadvantage to IgD-expressing B cells for developing into memory B cells. Surface immunoglobulin D (IgD) is co-expressed with IgM on naive mature B cells. Still, the role of surface IgD remains enigmatic even 50 years after its initial discovery. We here examined the in vivo role...

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Literature Corpus work: aedefd95-3a1b-5a7e-95b7-743fda9deb94
DOI: 10.1101/332361

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