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Article

IgD attenuates the IgM-induced anergy response in transitional and mature B cells.

Nature communications - 10 Nov 2016

Sabouri Zahra, Perotti Samuel, Spierings Emily, Humburg Peter, Yabas Mehmet, Bergmann Hannes, Horikawa Keisuke, Roots Carla, Lambe Samantha, Young Clara, Andrews T Dan, Field Matthew, Enders Anselm, Reed Joanne H, Goodnow Christopher C

Abstract excerpt

Self-tolerance by clonal anergy of B cells is marked by an increase in IgD and decrease in IgM antigen receptor surface expression, yet the function of IgD on anergic cells is obscure. Here we define the RNA landscape of the in vivo anergy response, comprising 220 induced sequences including a core set of 97. Failure to co-express IgD with IgM decreases overall expression of receptors for self-antigen, but...

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Source

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Identifiers

PMID: 27830696
DOI: 10.1038/ncomms13381
PMCID: PMC5109548

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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