Article
Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors.
The Journal of experimental medicine - 16 Jan 2009
Duty J Andrew, Szodoray Peter, Zheng Nai-Ying, Koelsch Kristi A, Zhang Qingzhao, Swiatkowski Mike, Mathias Melissa, Garman Lori, Helms Christina, Nakken Britt, Smith Kenneth, Farris A Darise, Wilson Patrick C
Abstract excerpt
Self-reactive B cells not controlled by receptor editing or clonal deletion may become anergic. We report that fully mature human B cells negative for surface IgM and retaining only IgD are autoreactive and functionally attenuated (referred to as naive IgD(+)IgM(-) B cells [B(ND)]). These B(ND) cells typically make up 2.5% of B cells in the peripheral blood, have antibody variable region genes in germline...
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