Article

Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia

2020-04-25

Abstract excerpt

Chronic pain states such as osteoarthritis (OA) are often associated with negative affect, including anxiety and depression. This is, in turn, associated with greater opioid analgesic use, potentially contributing to current and future opioid crises. We utilise an animal model to investigate the neurobiological mechanisms underlying increased opioid use associated with high anxiety and chronic pain. Combining a ge...

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Literature Corpus work: 3fd2103f-42c5-544d-ac74-7aea275dabc9
DOI: 10.1101/2020.04.24.057570

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