Metformin improves monosodium-iodoacetate-induced osteoarthritis via regulation of pain mediators and autophagy-lysosomal pathway.

Abstract excerpt

<h4>Background: </h4> Osteoarthritis (OA) is the most common degenerative arthritis associated with pain and cartilage destruction in the elderly. Its pathogenesis involves inflammatory pathways. Metformin is used to treat type 2 diabetes but also exhibits regulation of autophagy pathway. This study investigated the ability of metformin to ameliorate the severity of monosodium iodoacetate (MIA)-induced OA in rats....

Topics

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• Flavonoids
• Hyperalgesia
• Joints
• MAP Kinase Kinase 1
• Nociceptors
• Osteoarthritis
• Osteoarthritis Treatment and Mechanisms
• p38 Mitogen-Activated Protein Kinases

Identifiers and source

Literature Corpus work

d191a55c-10b7-5e86-a449-719b8fb239e7

DOI

10.21203/rs.2.23029/v1