Article

Enhancing sensitivity and controlling false discovery rate in somatic indel discovery using a latent variable model

2017-03-29

Abstract excerpt

Cancer is a genetic disorder in the first place. Therefore, next-generation sequencing (NGS) based discovery of somatically acquired genetic variants has gained widespread attention. Computational prediction of somatic variants, however, is affected by a variety of confounding factors. In addition to the uncertainties that one commonly encounters also in germline variation prediction, such as misplaced and/or inac...

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Literature Corpus work: aecd1db3-0422-578f-ae1b-da60c1a48744
DOI: 10.1101/121954

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