Lancet2: Improved and accelerated somatic variant calling with joint multi-sample local assembly graphs.

Abstract excerpt

Here, we present Lancet2, an open-source somatic variant caller designed to improve detection of small variants in short-read sequencing data. Lancet2 introduces significant enhancements, including: (i) Improved variant discovery and genotyping through partial order multiple sequence alignment of assembled haplotype contigs, and re-alignment of sample reads to the best supporting allele. (ii) Optimized somatic...

Topics

Join the communities discussing this publication.

• Algorithms
• Genetic Variation
• Haplotypes
• High-Throughput Nucleotide Sequencing
• Sequence Alignment