Article

Detection of somatic structural variants from short-read next-generation sequencing data

2019-11-13

Abstract excerpt

Somatic structural variants (SVs) play a significant role in cancer development and evolution, but are notoriously more difficult to detect than small variants from short-read next-generation sequencing (NGS) data. This is due to a combination of challenges attributed to the purity of tumour samples, tumour heterogeneity, limitations of short-read information from NGS, and sequence alignment ambiguities. In spite...

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Literature Corpus work: d47a6168-f728-5fad-ba2d-d6c56c633712
DOI: 10.1101/840751

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