Article

Calling Somatic SNVs and Indels with Mutect2

2019-12-02

Abstract excerpt

Mutect2 is a somatic variant caller that uses local assembly and realignment to detect SNVs and indels. Assembly implies whole haplotypes and read pairs, rather than single bases, as the atomic units of biological variation and sequencing evidence, improving variant calling. Beyond local assembly and alignment, Mutect2 is based on several probabilistic models for genotyping and filtering that work well with and wi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 52af24e0-c240-5ff7-9185-1177f54c3d7b
DOI: 10.1101/861054

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Calling Somatic SNVs and Indels with Mutect2DOI 10.1101/861054Read

SNVSniffer: an integrated caller for germline and somatic single-nucleotide and indel mutations.Semantic proximity Read

Lancet2: Improved and accelerated somatic variant calling with joint multi-sample local assembly graphs.Semantic proximity Read

Lancet2: Improved and accelerated somatic variant calling with joint multi-sample local assembly graphsSemantic proximity Read

smCounter2: an accurate low-frequency variant caller for targeted sequencing data with unique molecular identifiers.Semantic proximity Read

Using VarScan 2 for Germline Variant Calling and Somatic Mutation Detection.Semantic proximity Read

Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs.Semantic proximity Read

TNscope: Accurate Detection of Somatic Mutations with Haplotype-based Variant Candidate Detection and Machine Learning FilteringSemantic proximity Read

smCounter2: an accurate low-frequency variant caller for targeted sequencing data with unique molecular identifiersSemantic proximity Read

Accurate calling of low-frequency somatic mutations by sample-specific modeling of error ratesSemantic proximity Read

Strelka2: Fast and accurate variant calling for clinical sequencing applicationsSemantic proximity Read

Strelka2: fast and accurate calling of germline and somatic variants.Semantic proximity Read

Mining Thousands of Genomes to Classify Somatic and Pathogenic Structural VariantsSemantic proximity Read