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Article

Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs.

Bioinformatics (Oxford, England) - 15 Jul 2012

Saunders Christopher T, Wong Wendy S W, Swamy Sajani, Becq Jennifer, Murray Lisa J, Cheetham R Keira

Abstract excerpt

MOTIVATION: Whole genome and exome sequencing of matched tumor-normal sample pairs is becoming routine in cancer research. The consequent increased demand for somatic variant analysis of paired samples requires methods specialized to model this problem so as to sensitively call variants at any practical level of tumor impurity. RESULTS: We describe Strelka, a method for somatic SNV and small indel detection from...

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PMID: 22581179
DOI: 10.1093/bioinformatics/bts271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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