Article

Lancet2: Improved and accelerated somatic variant calling with joint multi-sample local assembly graphs

2025-02-23

Abstract excerpt

Here, we present Lancet2, an open-source somatic variant caller designed to improve detection of small variants in short-read sequencing data. Lancet2 introduces significant enhancements, including: 1) Improved variant discovery and genotyping through partial order multiple sequence alignment of assembled haplotype contigs and re-alignment of sample reads to the best supporting allele. 2) Optimized somatic variant...

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Literature Corpus work: fdc9ab7c-c234-5b2b-889b-d1e399de2c94
DOI: 10.1101/2025.02.18.638852

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